Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis.

@article{Dong1998AutoantibodiesTD,
  title={Autoantibodies to DEK oncoprotein in a patient with systemic lupus erythematosus and sarcoidosis.},
  author={Xu Dong and Mary Ann Michelis and Jianping Wang and Romen Bose and T deLange and Westley H. Reeves},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 8},
  pages={
          1505-10
        }
}
A patient was identified with an unusual autoimmune syndrome consisting of systemic lupus erythematosus and sarcoidosis. Her serum contained extremely high levels of autoantibodies to the DEK protooncogene product. The patient's serum was used to clone a dek complementary DNA, which was expressed as a histidine-tagged fusion protein in Escherichia coli. Using affinity-purified recombinant DEK protein, anti-DEK autoantibodies were found in the patient's serum at a titer of 1:10(6) by enzyme… CONTINUE READING

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