Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.

@article{Shi2011AutoantibodiesRC,
  title={Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage.},
  author={Jing Shi and Rachel Knevel and Parawee Suwannalai and Michael P M van der Linden and George M. C. Janssen and Peter A. van Veelen and Nivine E W Levarht and Annette H van der Helm-van Mil and Anthony Cerami and Tom W. J. Huizinga and Ren{\'e} E. M. Toes and Leendert A Trouw},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 42},
  pages={17372-7}
}
Autoimmune responses against posttranslationally modified antigens are a hallmark of several autoimmune diseases. For example, antibodies against citrullinated protein antigens (ACPA) have shown their relevance for the prognosis and diagnosis of rheumatoid arthritis (RA), and have been implicated in disease pathogenesis. It is conceivable that other autoantibody systems, recognizing other posttranslationally modified proteins, are also present in RA. Here, we describe the presence of an… CONTINUE READING
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