Autoantibodies in neuroimmunological diseases; relevance of fine specificity

@article{Kusunoki2013AutoantibodiesIN,
  title={Autoantibodies in neuroimmunological diseases; relevance of fine specificity},
  author={Susumu Kusunoki},
  journal={Experimental Neurology},
  year={2013},
  volume={250},
  pages={219-220}
}
  • S. Kusunoki
  • Published 1 December 2013
  • Biology, Medicine
  • Experimental Neurology
View on Elsevier
doi.org
4 Citations
Background Citations
1

4 Citations

Prevalence of neurofascin-155 antibodies in patients with multiple sclerosis
From PNS to CNS: characteristics of anti-neurofascin 186 neuropathy in 16 cases
TLDR
It is worth noting that quite a few patients show CNS-impaired signs only, and cranial MRI is essential for the screening of CNS involvement, and CSF white blood cell counts were found significantly elevated in CNS-involved patients compared with patients of PNS group.
Inflammation in neurodegenerative diseases – an update
TLDR
A better understanding of how immune responses are involved in neuronal damage and regeneration will be essential to develop effective therapies to improve quality of life, and mitigate the personal, economic and social impact of neurodegenerative disorders.
Perspectives on the imperatives, opportunities and challenges for point-of-care diagnostics in systemic lupus erythematosus
TLDR
The development of POCD in systemic lupus erythematosus would be facilitated by evidence-based use of a number of well-defined, disease-specific biomarkers, including multiplexed bead-based technologies, lateral flow, novel nanomaterials and lab-on-a-chip microfluidics.

References

SHOWING 1-10 OF 12 REFERENCES
Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis
Neurofascin as a target for autoantibodies in peripheral neuropathies
TLDR
Autoantibodies to NF are detected in a very small proportion of patients with AIDP and patients with CIDP, but may nevertheless be pathogenic in these cases.
Neurofascin as a novel target for autoantibody-mediated axonal injury
TLDR
A novel mechanism of immune-mediated axonal injury that can contribute to axonal pathology in MS is identified and identified through a proteomics-based approach.
Quantification and functional characterization of antibodies to native aquaporin 4 in neuromyelitis optica.
TLDR
A novel bioassay for quantification and characterization of human anti-AQP4 antibodies based on high-level expression of native AQP4 protein on the surface of human astroglioma cells is developed and validated, demonstrating the potential of bioassays to characterize biologically relevant antibodies in human autoimmune diseases.
The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.
TLDR
A revised understanding of the complexities in ganglioside membrane topology provides a mechanistic account for wide variations in the neuropathic potential of anti-GM1 antibodies.
Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis
Ganglioside complexes as new target antigens in Guillain–Barré syndrome
Antibodies specific for a complex of gangliosides GD1a and GD1b (GD1a/GD1b) were found in sera from eight of 100 patients with Guillain–Barré syndrome (GBS) by the use of enzyme‐linked immunosorbent…
GD1b-specific antibody induces ataxia in Guillain-Barré syndrome
TLDR
The reactivities of anti-GD1b IgG to such complexes are different between ataxic and nonataxic patients, and the addition of another ganglioside may cause conformational change of GD1b.
Effects of phospholipids on antiganglioside antibody reactivity in GBS
Sodium channel β1 and β3 subunits associate with neurofascin through their extracellular immunoglobulin-like domain
TLDR
It is shown that β1 subunits associate with neurofascin, a neuronal cell adhesion molecule that plays a key role in the assembly of nodes of Ranvier, confirming the proposed function of this domain as a cellAdhesion molecule.
...
...