Autoantibodies in mothers of children with neonatal liver disease.

  title={Autoantibodies in mothers of children with neonatal liver disease.},
  author={Joanna M Burch and Ronald J. Sokol and Michael R. Narkewicz and Morris Reichlin and Mark Barton Frank and Todd Mackenzie and Lela A. Lee},
  journal={Journal of pediatric gastroenterology and nutrition},
  volume={37 3},
OBJECTIVES Neonatal lupus erythematosus (NLE) is associated with maternal anti-Ro/La autoantibodies. It is characterized by heart block and/or cutaneous skin lesions, and occasionally liver disease. This study was performed to determine whether idiopathic neonatal cholestasis (INC) represents NLE without its cardiac or cutaneous findings. METHODS Sera were obtained for autoantibody analysis from mothers of children with INC (N = 11), biliary atresia (N = 25), other liver disease excluding… CONTINUE READING