Autoantibodies as predictors of disease

  title={Autoantibodies as predictors of disease},
  author={Robert Hal Scofield},
  journal={The Lancet},

2 Non-thyroid autoantibodies in autoimmune thyroid disease

There are no large-scale trials that have shown the cost–benefit ratio of autoantibody screening for autoimmunity screening, and clinicians must use individual judgement combined with heightened awareness to identify who to test.

Non-thyroid autoantibodies in autoimmune thyroid disease.

  • A. Weetman
  • Medicine, Biology
    Best practice & research. Clinical endocrinology & metabolism
  • 2005

Prediction and prevention of autoimmune skin disorders

Although large body of evidence has accumulated on characteristic autoantibodies, susceptible genes and environmental factors, many more large scale studies are needed to assess their predictive value, the preventive measurements and the means to apply them to clinical management of healthy population and high-risk individuals.

Prediction and prevention of autoimmune diseases: additional aspects of the mosaic of autoimmunity

The aim of this article is to review the major risk factors for autoimmune disease, both hereditary and environmental, and so to help define those future criteria for preventive treatment.

Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders

The example of PTPN22 illustrates how human genetics is likely to provide new insights into pathogenesis and unravel new relationships among the autoimmune diseases.

Organ specific-autoantibodies: Their role as markers and predictors of disease

The wide range of affected organ systems and the overlap between different diseases pose several clinical challenges, and some of the problems frequently encountered are assessment of risk.

On the Trail of Diseases, Years Before They Strike - Auto Antibodies

The ability to predict auto immune diseases, or rather their clinical manifestations lead to the prospect of screening healthy individuals for auto antibodies, which will enable to prevent life threatening manifestations and help to treat or even prevent overt autoimmune diseases.

The diagnostic role of autoantibodies in the prediction of organ-specific autoimmune diseases

  • R. Tozzoli
  • Medicine, Biology
    Clinical chemistry and laboratory medicine
  • 2008
This review examines the various autoantibodies of demonstrated predictive role in organ-specific autoimmune diseases and it introduces the state-of-the-art in the detection of multiple autoantIBodies with proteomic systems.

Studies on the role of autoantibodies and autoantigens in rheumatoid arthritis and myositis

The aims of the thesis were to understand the molecular mechanisms underlying the autoimmune component (specifically, the auto-antibody and -antigen dynamics) in RA and myositis; and to develop ACPA neutralizing compounds.

Spectrum of Thyroid Disorders in Sero Positive Rheumatoid Arthritis

Thyroid dysfunction is prevalent in patients with rheumatoid arthritis with percentage of 41.8%, subclinical hypothyroidism is the most common thyroid dysfunction encountered followed by overt hypothy thyroid dysfunction (3.6%), hyperthyroidistan is very rare seen only 0.3% patients.



Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction.

Imaging of adrenal glands, genetic tests, and biochemical analysis have been shown to contribute to early and correct diagnosis of primary non-autoimmune AD in the cases of hypoadrenalism with undetectable adrenal autoantibodies.

Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors.

It is concluded that IgM-RF and anti-CCP testing with appropriately high specificity may assist in the early detection of RA in high-risk populations.

Autoimmune type 1 diabetes: resolved and unresolved issues.

The demonstration of the presence of autoantibodies years before the onset of clinical symptoms has made it possible to identify individuals at high risk of developing type 1 diabetes and to initiate therapeutic intervention trials on relatively small numbers of subjects, suggesting that to a very large degree,type 1 diabetes is a predictable disease.

Development of autoantibodies before the clinical onset of systemic lupus erythematosus.

The onset and progression of autoantibody development before the clinical diagnosis of systemic lupus erythematosus is investigated, with a progressive accumulation of specificAutoantibodies before the onset of SLE, while patients are still asymptomatic.

Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis.

Anti-CCP antibody and RFs of all isotypes predated the onset of RA by several years, indicating that citrullination and the production of anti- CCP and RF autoantibodies are early processes in RA.

I. Adrenal cortex and steroid 21-hydroxylase autoantibodies in adult patients with organ-specific autoimmune diseases: markers of low progression to clinical Addison's disease.

The detection of ACA/21-OH antibodies in adults is a marker of low progression toward clinical Addison's disease and was more frequent in patients with subclinical hypoadrenalism, high titers of ACA and higher levels of 21- OH antibodies, complement-fixing ACA and HLA-DR3 status.

Time course of 21-hydroxylase antibodies and long-term remission of subclinical autoimmune adrenalitis after corticosteroid therapy: case report.

The disappearance of both 21OHAb and ACA and their prolonged absence during the follow-up suggest that corticosteroid treatment can induce long-term remission of subclinical adrenal insufficiency and prevent the onset of the clinical phase of the disease.

II. Adrenal cortex and steroid 21-hydroxylase autoantibodies in children with organ-specific autoimmune diseases: markers of high progression to clinical Addison's disease.

In children with autoimmune endocrine diseases, ACA/21-hydroxylase autoantibodies are important predictive markers for the development of Addison's disease.

Cell-mediated immunity and postpartum thyroid dysfunction: a possibility for the prediction of disease?

It is concluded that TPO-Ab+ pregnant women who develop PPTD show several CMI abnormalities other than those seen in normal pregnant women, such as persistently lower percentage of NK cells, a lowered monocyte polarization, and a raised percentage of major histocompatibility complex-class II+CD3+ T cells.