Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown

@inproceedings{Yung2012AutoantibodiesAR,
  title={Autoantibodies and Resident Renal Cells in the Pathogenesis of Lupus Nephritis : Getting to Know the Unknown},
  author={Susan Yung and Tak Mao Chan},
  booktitle={Clinical & developmental immunology},
  year={2012}
}
Systemic lupus erythematosus is characterized by a breakdown of self-tolerance and production of autoantibodies. Kidney involvement (i.e., lupus nephritis) is both common and severe and can result in permanent damage within the glomerular, vascular, and tubulo-interstitial compartments of the kidney, leading to acute or chronic renal failure. Accumulating evidence shows that anti-dsDNA antibodies play a critical role in the pathogenesis of lupus nephritis through their binding to cell surface… CONTINUE READING

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