Autoantibodies against type I IFNs in patients with life-threatening COVID-19

  title={Autoantibodies against type I IFNs in patients with life-threatening COVID-19},
  author={P. Bastard and Lindsey B Rosen and Q. Zhang and E. Michailidis and H. Hoffmann and Y. Zhang and K. Dorgham and Q. Philippot and J. Rosain and V. B{\'e}ziat and J{\'e}r{\'e}my Manry and Elana Shaw and Liis Haljasm{\"a}gi and P. Peterson and L. Lorenzo and Lucy Bizien and S. Trouillet-Assant and Kerry Dobbs and A. D. de Jes{\'u}s and A. Belot and Anne Kallaste and Emilie Catherinot and Y. Tandjaoui-Lambiotte and J{\'e}r{\'e}mie Le Pen and G. Kerner and B. Bigio and Y. Seeleuthner and R. Yang and A. Bolze and A. Spaan and O. Delmonte and M. Abers and A. Aiuti and G. Casari and V. Lampasona and L. Piemonti and F. Ciceri and K. Bilguvar and R. Lifton and M. Vasse and D. Smadja and M. Migaud and J. Hadjadj and B. Terrier and D. Duffy and L. Quintana-Murci and D. van de Beek and L. Roussel and D. Vinh and S. Tangye and F. Haerynck and D. Dalmau and J. Martinez-Picado and P. Brodin and M. Nussenzweig and S. Boisson-Dupuis and C. Rodr{\'i}guez-Gallego and G. Vogt and T. Mogensen and Andrew J. Oler and Jingwen Gu and P. Burbelo and J. Cohen and A. Biondi and L. Bettini and Mariella D'Angi{\`o} and P. Bonfanti and P. Rossignol and J. Mayaux and F. Rieux-Laucat and E. Husebye and F. Fusco and M. Ursini and L. Imberti and A. Sottini and S. Paghera and E. Quiros-Roldan and Camillo Rossi and R. Castagnoli and D. Montagna and A. Licari and G. Marseglia and X. Duval and J. Ghosn and J. Tsang and R. Goldbach-Mansky and K. Kisand and M. Lionakis and A. Puel and S. Zhang and S. Holland and G. Gorochov and E. Jouanguy and C. Rice and A. Cobat and L. Notarangelo and L. Abel and H. Su and Jean-Laurent Casanova},
  • P. Bastard, Lindsey B Rosen, +96 authors Jean-Laurent Casanova
  • Published 2020
  • Medicine
  • Science
  • The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this… CONTINUE READING
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