Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP.

@article{Woods1984AutoantibodiesAT,
  title={Autoantibodies against the platelet glycoprotein IIb/IIIa complex in patients with chronic ITP.},
  author={Virgil L. Woods and Edward Hyunseung Oh and Debby Mason and Robert McMillan},
  journal={Blood},
  year={1984},
  volume={63 2},
  pages={
          368-75
        }
}
Chronic idiopathic thrombocytopenic purpura (ITP) is caused by an antibody reactive with platelet-associated antigens. The present studies provide direct evidence that some patients with chronic ITP have autoantibodies against the platelet glycoprotein (GP) IIb/IIIa complex. Microtiter wells, coated with a monoclonal antibody (2G12) specific for GPIIb/GPIIIa were reacted with GPIIb/GPIIIa contained in a platelet extract. Control wells containing the same antibody were reacted with a cell… CONTINUE READING

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