Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria.

@article{Iwamoto1993AutoantibodiesAT,
  title={Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria.},
  author={Kazumasa Iwamoto and David Michael Francis and Clive E Grattan and John Hakimi and Jarema P. Kochan and Malcolm Greaves},
  journal={The New England journal of medicine},
  year={1993},
  volume={328 22},
  pages={1599-604}
}
BACKGROUND Most urticarias are induced by vasoactive mediators such as histamine released from mast cells. Although mast cells are activated by allergens through cross-linking of cell-surface--bound IgE, this mechanism does not appear to explain most cases of chronic urticaria, which, when allergic, infectious, drug-induced, or physical causes cannot be identified, are classified as idiopathic. METHODS We recruited 26 patients with chronic idiopathic urticaria, in whom intradermal injection… CONTINUE READING
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