Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker of Hashimoto's encephalopathy

@article{Fujii2005AutoantibodiesAT,
  title={Autoantibodies against the amino terminal of $\alpha$-enolase are a useful diagnostic marker of Hashimoto's encephalopathy},
  author={Akihiro Fujii and Makoto Yoneda and T. Ito and Osamu Yamamura and Satoko Satomi and Henry Higa and Akihiro Kimura and M Suzuki and Masahiro Yamashita and T. Yuasa and H Suzuki and Masaru Kuriyama},
  journal={Journal of Neuroimmunology},
  year={2005},
  volume={162},
  pages={130-136}
}
We investigated autoantibodies and their epitope(s) in Hashimoto's encephalopathy associated with Hashimoto's thyroiditis. In a proteomic analysis, they proved to recognize alpha-enolase. We further searched the epitope region in alpha-enolase using different regions of recombinant proteins expressed in cultured human cells. The amino terminal region was recognized by autobodies from a much higher proportion of patients with Hashimoto's encephalopathy (83.3%; 5/6) than from patients with… Expand
High prevalence of serum autoantibodies against the amino terminal of α-enolase in Hashimoto's encephalopathy
TLDR
It is demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoant ibodies, are emphasized as useful serological diagnostic markers of HE. Expand
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[Hashimoto's encephalopathy].
  • M. Yoneda
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
  • 2015
TLDR
The clinicoimmunological features of 80 cases of HE with serum anti-NAE Abs from institutions throughout Japan found that the serum autoantibodies against the NH2-terminal of α-enolase (NAE) can serve as a highly specific diagnostic biomarker for HE. Expand
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Hashimoto encephalopathy
Hashimoto encephalopathy (HE) is an autoimmune encephalopathy associated with autoimmune chronic thyroiditis. The clinical entity and nosology of HE have long been debated. Recently, newExpand
Gerstmann's Syndrome in a Patient Double-positive for Antibodies against the N-methyl-D-aspartate Receptor and NH2-terminal of α-enolase
TLDR
A 36-year-old Japanese woman presented with Gerstmann's syndrome followed by jerky involuntary movements, seizure, autonomic instability, and consciousness disturbance, suggesting that the diagnosis of Hashimoto encephalopathy requires the reasonable exclusion of alternative diagnoses, including anti-NMDAR encephalitis. Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Proteomic analysis of human brain identifies α‐enolase as a novel autoantigen in Hashimoto's encephalopathy
Hashimoto's encephalopathy (HE) is a rare autoimmune disease associated with Hashimoto's thyroiditis (HT). To identify the HE‐related autoantigens, we developed a human brain proteome map usingExpand
Identification of the 49-kDa Autoantigen Associated with Lymphocytic Hypophysitis as α-Enolase
TLDR
This study is the first to indicate a role for -enolase as an autoantigen in lymphocytic hypophysitis, and thisAutoantigen has a molecular mass of 49 kDa, a cytosolic localization, and a ubiquitous tissue distribution. Expand
Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients
TLDR
Results indicate that anti-neuronal autoantibodies may be associated with the pathogenesis of Hashimoto's encephalopathy. Expand
Hashimoto's encephalopathy: epidemiologic data and pathogenetic considerations
TLDR
An estimate of the prevalence of the disease, verifying the association with HT and investigating the pathogenetic role of anti-thyroid antibodies are sought, and the intrathecal synthesis of autoantibodies is a distinctive marker of this elusive condition. Expand
Creutzfeldt-Jakob disease associated with high titer of antithyroid autoantibodies: case report and literature review
TLDR
In patients with unclear symptomatology and rapid onset of myoclonus, dementia and ataxia, the presence of antithyroid antibodies should be examined and if their levels are abnormal, corticosteroid therapy remains mandatory. Expand
Hashimoto encephalopathy: syndrome or myth?
TLDR
The combination of encephalopathy, high serum antithyroid antibody concentrations, and responsiveness to glucocorticoid therapy seems unlikely to be due to chance, but there is no evidence of a pathogenic role for the antibodies, which are probably markers of some other autoimmune disorder affecting the brain. Expand
Surface expression of a glycolytic enzyme, α‐enolase, recognized by autoantibodies in connective tissue disorders
TLDR
The results show that α‐enolase, an autoantigen in connective tissue diseases, is a cytoplasmic enzyme which is also expressed on the cell membrane, with which it is strongly associated. Expand
Encephalopathy associated with Hashimoto thyroiditis: Diagnosis and treatment
TLDR
Six patients with Hashimoto thyroiditis and associated encephalopathy are described and compared and it is shown that two types of initial clinical presentation can be differentiated: a vasculitic type with stroke-like episodes and mild cognitive impairment in nine patients, and a diffuse progressive type with dementia, seizures, psychotic episodes or altered consciousness in 11 patients. Expand
Manifestation of Hashimoto’s Encephalopathy Years before Onset of Thyroid Disease
Patients with Hashimoto’s encephalopathy (HE), a steroid-responsive disorder, associated with Hashimoto’s disease and high levels of thyroid-related autoantibodies usually present with a subacuteExpand
Hashirnoto's encephalopathy
TLDR
Patients with a relapsing encephalopathy in association with Hashimoto's disease and high titers of anti-thyroid antibodies should be recognized as a definite neurologic entity and added to the list of CNS complications of thyroid disease. Expand
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