Autoantibodies against the amino terminal of α-enolase are a useful diagnostic marker of Hashimoto's encephalopathy

  title={Autoantibodies against the amino terminal of $\alpha$-enolase are a useful diagnostic marker of Hashimoto's encephalopathy},
  author={Akihiro Fujii and Makoto Yoneda and T. Ito and Osamu Yamamura and Satoko Satomi and Henry Higa and Akihiro Kimura and M Suzuki and Masahiro Yamashita and T. Yuasa and H Suzuki and Masaru Kuriyama},
  journal={Journal of Neuroimmunology},
We investigated autoantibodies and their epitope(s) in Hashimoto's encephalopathy associated with Hashimoto's thyroiditis. In a proteomic analysis, they proved to recognize alpha-enolase. We further searched the epitope region in alpha-enolase using different regions of recombinant proteins expressed in cultured human cells. The amino terminal region was recognized by autobodies from a much higher proportion of patients with Hashimoto's encephalopathy (83.3%; 5/6) than from patients with… Expand
High prevalence of serum autoantibodies against the amino terminal of α-enolase in Hashimoto's encephalopathy
It is demonstrated that anti-NAE autoantibodies, in addition to anti-thyroid autoant ibodies, are emphasized as useful serological diagnostic markers of HE. Expand
High prevalence of serum anti-NH2-terminal of α-enolase antibodies in patients with multiple system atrophy and corticobasal syndrome
Serum anti-NAE antibodies might represent a prognostic marker in the clinical course of MSA and CBS, and the duration from onset to a wheelchair-bound state in seropositive MSA customers tended to be shorter than that in seronegative MSA patients. Expand
[Hashimoto's encephalopathy].
  • M. Yoneda
  • Medicine
  • Nihon rinsho. Japanese journal of clinical medicine
  • 2015
The clinicoimmunological features of 80 cases of HE with serum anti-NAE Abs from institutions throughout Japan found that the serum autoantibodies against the NH2-terminal of α-enolase (NAE) can serve as a highly specific diagnostic biomarker for HE. Expand
Anti-thyroperoxidase antibodies from patients with Hashimoto's encephalopathy bind to cerebellar astrocytes
Specific astrocyte binding of anti-TPO aAb suggests a role of these aAb in the HE pathogenesis, and in immunofluorescence assays on monkey brain cerebellum sections, both HE patients' sera and anti- TPO monoclonal antibodies (mAb) were able to bind cerebellar cells expressing glial fibrillary acid protein. Expand
Hashimoto’s encephalopathy presenting with progressive cerebellar ataxia
A 41-year-old woman, who had a normal dietary history, became aware of a slight unsteadiness while walking and mild dysarthria in December 2003, and was admitted to the University of Fukui hospital in September 2004 because she could not stand or walk without support. Expand
Antifibroblast antibodies from systemic sclerosis patients bind to α-enolase and are associated with interstitial lung disease
In SSc, AFA recognise α-enolase and are associated with ILD and antitopoisomerase antibodies. Expand
Experimental evidence for alpha enolase as one potential autoantigen in the pathogenesis of both autoimmune thyroiditis and its related encephalopathy.
The results suggest that ENO1Ab can cause thyrocyte damage via ADCC effect and impair cerebral function by disrupting the blood-brain barrier. Expand
Investigation of three potential autoantibodies in Sjogren's syndrome and associated MALT lymphoma
Collectively, this study has successfully identified a panel of potential autoantigens that are progressively up-regulated during the development of pSS and its progression to MALT lymphoma. Expand
Hashimoto encephalopathy
Hashimoto encephalopathy (HE) is an autoimmune encephalopathy associated with autoimmune chronic thyroiditis. The clinical entity and nosology of HE have long been debated. Recently, newExpand
Gerstmann's Syndrome in a Patient Double-positive for Antibodies against the N-methyl-D-aspartate Receptor and NH2-terminal of α-enolase
A 36-year-old Japanese woman presented with Gerstmann's syndrome followed by jerky involuntary movements, seizure, autonomic instability, and consciousness disturbance, suggesting that the diagnosis of Hashimoto encephalopathy requires the reasonable exclusion of alternative diagnoses, including anti-NMDAR encephalitis. Expand


Proteomic analysis of human brain identifies α‐enolase as a novel autoantigen in Hashimoto's encephalopathy
Hashimoto's encephalopathy (HE) is a rare autoimmune disease associated with Hashimoto's thyroiditis (HT). To identify the HE‐related autoantigens, we developed a human brain proteome map usingExpand
Identification of the 49-kDa Autoantigen Associated with Lymphocytic Hypophysitis as α-Enolase
This study is the first to indicate a role for -enolase as an autoantigen in lymphocytic hypophysitis, and thisAutoantigen has a molecular mass of 49 kDa, a cytosolic localization, and a ubiquitous tissue distribution. Expand
Anti-neuronal autoantibody in Hashimoto's encephalopathy: neuropathological, immunohistochemical, and biochemical analysis of two patients
Results indicate that anti-neuronal autoantibodies may be associated with the pathogenesis of Hashimoto's encephalopathy. Expand
Hashimoto's encephalopathy: epidemiologic data and pathogenetic considerations
An estimate of the prevalence of the disease, verifying the association with HT and investigating the pathogenetic role of anti-thyroid antibodies are sought, and the intrathecal synthesis of autoantibodies is a distinctive marker of this elusive condition. Expand
Creutzfeldt-Jakob disease associated with high titer of antithyroid autoantibodies: case report and literature review
In patients with unclear symptomatology and rapid onset of myoclonus, dementia and ataxia, the presence of antithyroid antibodies should be examined and if their levels are abnormal, corticosteroid therapy remains mandatory. Expand
Hashimoto encephalopathy: syndrome or myth?
The combination of encephalopathy, high serum antithyroid antibody concentrations, and responsiveness to glucocorticoid therapy seems unlikely to be due to chance, but there is no evidence of a pathogenic role for the antibodies, which are probably markers of some other autoimmune disorder affecting the brain. Expand
Surface expression of a glycolytic enzyme, α‐enolase, recognized by autoantibodies in connective tissue disorders
The results show that α‐enolase, an autoantigen in connective tissue diseases, is a cytoplasmic enzyme which is also expressed on the cell membrane, with which it is strongly associated. Expand
Encephalopathy associated with Hashimoto thyroiditis: Diagnosis and treatment
Six patients with Hashimoto thyroiditis and associated encephalopathy are described and compared and it is shown that two types of initial clinical presentation can be differentiated: a vasculitic type with stroke-like episodes and mild cognitive impairment in nine patients, and a diffuse progressive type with dementia, seizures, psychotic episodes or altered consciousness in 11 patients. Expand
Manifestation of Hashimoto’s Encephalopathy Years before Onset of Thyroid Disease
Patients with Hashimoto’s encephalopathy (HE), a steroid-responsive disorder, associated with Hashimoto’s disease and high levels of thyroid-related autoantibodies usually present with a subacuteExpand
Hashirnoto's encephalopathy
Patients with a relapsing encephalopathy in association with Hashimoto's disease and high titers of anti-thyroid antibodies should be recognized as a definite neurologic entity and added to the list of CNS complications of thyroid disease. Expand