Autoantibodies against pancreatic beta-cells: characterization by western blot analysis in the non-obese diabetic (NOD) mouse.

@article{Villa1992AutoantibodiesAP,
  title={Autoantibodies against pancreatic beta-cells: characterization by western blot analysis in the non-obese diabetic (NOD) mouse.},
  author={M. C. Ruiz de Villa and Chantal B{\'e}court and H P Gia and Pascal Semp{\'e} and M M Portier and J. F. Bach and Christian Boitard},
  journal={Journal of autoimmunity},
  year={1992},
  volume={5 1},
  pages={47-58}
}
The NOD mouse is a relevant model for studying autoimmune diabetes. As in human insulin-dependent diabetes mellitus, the nature of the autoantigen towards which the immune system is directed remains to be clarified. It has been shown that T cells are central to the disease process. However, autoantibodies may be used as a probe to identify islet… CONTINUE READING