Autoantibodies against opioid or glutamate receptors are associated with changes in morphine reward and physical dependence in mice

@article{Capone2007AutoantibodiesAO,
  title={Autoantibodies against opioid or glutamate receptors are associated with changes in morphine reward and physical dependence in mice},
  author={Francesca Capone and Walter Adriani and Maria Shumilina and Galina A Izykenova and Oleg Konstantinovich Granstrem and Svetlana A. Dambinova and Giovanni Laviola},
  journal={Psychopharmacology},
  year={2007},
  volume={197},
  pages={535-548}
}
Possible interactions between nervous and immune systems during opioid addiction remain elusive. Recombinant μ–δ opioid receptors (MDOR) and the glutamate receptor 1 (GluR1) subunit of amino-3-hydroxy-5-methyl-4-isoxazole propionic acid glutamate receptors are involved in acute and chronic effects of morphine. Elevated levels of autoantibodies (aAbs) to these receptors were demonstrated in heroin human addicts and in animal models. This study characterized the role of aAbs to these receptors in… CONTINUE READING
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