Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis.

@article{Lozano1988AutoantibodiesAN,
  title={Autoantibodies against nuclear envelope-associated proteins in primary biliary cirrhosis.},
  author={Francisco Lozano and Albert Pares and Luis Borche and M. Enjuanes Plana and T. M{\'e}ndez Gallart and Jose J. Rodes and Jordi Vives},
  journal={Hepatology},
  year={1988},
  volume={8 4},
  pages={
          930-8
        }
}
An antinuclear immunofluorescence pattern displaying a thin ring confined to the nuclear envelope was assessed in sera from 38 patients with primary biliary cirrhosis and in sera from a control group of 277 patients with other antinuclear antibody-positive diseases. This rim-like antinuclear reactivity was present in sera from 20 primary biliary cirrhosis patients (52.6%) but in only two patients from the control group (0.7%) (p less than 0.001). Furthermore, this autoantibody was present in… CONTINUE READING
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