Autoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids from Pug dogs with necrotizing meningoencephalitis.

@article{Shibuya2007AutoantibodiesAG,
  title={Autoantibodies against glial fibrillary acidic protein (GFAP) in cerebrospinal fluids from Pug dogs with necrotizing meningoencephalitis.},
  author={Masahiro Shibuya and Naoaki Matsuki and K. Fujiwara and Shinobu Imajoh-Ohmi and Hiroyuki Fukuda and Ngoc Thi Pham and Satoshi Tamahara and Kenichiro Ono},
  journal={The Journal of veterinary medical science},
  year={2007},
  volume={69 3},
  pages={241-5}
}
Cerebrospinal fluids (CSFs) from 9 Pug dogs with necrotizing meningoencephalitis (NME: Pug dog encephalitis) were examined to identify the antigens for anti-astrocyte autoantibodies. Each CSF exhibited a positive reaction to the cytoplasm of cultured canine astrocytes by an indirect fluorescent antibody test. In an immunoblotting analysis on normal canine brain proteins, eight of 9 CSFs showed a common band of 52 kDa, corresponding to glial fibrillary acidic protein (GFAP), and all of 9 CSFs… CONTINUE READING

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