Autoantibodies against cardiac β(1)-adrenoceptor do not affect the low-affinity state β(1)-adrenoceptor-mediated inotropy in rat cardiomyocytes.

@article{Abdelkrim2012AutoantibodiesAC,
  title={Autoantibodies against cardiac β(1)-adrenoceptor do not affect the low-affinity state β(1)-adrenoceptor-mediated inotropy in rat cardiomyocytes.},
  author={Mohammed Amine Abdelkrim and Mohamed Yassine Mallem and G{\'e}rard Chatagnon and Marc Gogny and J Cl Desfontis and Jacques Noireaud},
  journal={Canadian journal of physiology and pharmacology},
  year={2012},
  volume={90 4},
  pages={407-14}
}
Circulating autoantibodies directed against the 2nd extracellular loop (EL-2) of β(1)-adrenoceptors (β(1)-AABs) have been detected in the serum of patients with various cardiovascular pathologies. β(1)-AABs induce agonistic, positive inotropic effects via β(1)-adrenoceptors (β(1)ARs). In the mammalian heart, β(1)-AR can exist in 2 distinct activated configurations (the so-called high- and low-affinity states). The aim of the present study was to investigate whether the action of β(1)-AAB is… CONTINUE READING