Autoantibodies against alpha -MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients.

@article{Fetissov2002AutoantibodiesAA,
  title={Autoantibodies against alpha -MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients.},
  author={Sergue{\"i} O. Fetissov and Jarmila Hallman and Lars Oreland and Britt af Klinteberg and Eva Grenb{\"a}ck and A. G. Hulting and Tomas G M H{\"o}kfelt},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2002},
  volume={99 26},
  pages={17155-60}
}
The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alpha-MSH) and synthesizing neuropeptide Y, respectively. We report here that 42 of 57 (74%) AN andor BN patients studied had in their plasma Abs that bind to melanotropes andor… CONTINUE READING
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