Autoantibodies against a 210kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis

@article{Itoh1998AutoantibodiesAA,
  title={Autoantibodies against a 210kDa glycoprotein of the nuclear pore complex as a prognostic marker in patients with primary biliary cirrhosis},
  author={S Itoh and Takafumi Ichida and Toshiaki Yoshida and Akihito Hayakawa and M Uchida and T Tashiro-Itoh and Yasunobu Matsuda and Kiyoshi Ishihara and Hitoshi Asakura},
  journal={Journal of Gastroenterology and Hepatology},
  year={1998},
  volume={13}
}
It has been reported that the presence of anti‐nuclear antibody against a 210kDa glycoprotein of nuclear pore complex (anti‐gp210) is highly specific for primary biliary cirrhosis (PBC). The aim of the present study was to investigate the significance of anti‐gp210, especially as a prognostic marker. The presence of anti‐gp210 was ascertained in 113 patients with PBC and 162 controls by indirect immunofluorescence assay using HepG2 cells and immunoblotting analysis using nuclear extracts from HeLa… Expand
Profile and clinical significance of anti-nuclear envelope antibodies found in patients with primary biliary cirrhosis: a multicenter study.
TLDR
The presence of anti-p62 complex antibody may be related with the progressive or advanced state of PBC, and the confirmation of Scheuer's stage IV was found to be statistically significant. Expand
Anti‐p97/VCP Antibodies: An Autoantibody Marker for a Subset of Primary Biliary Cirrhosis Patients with Milder Disease?
TLDR
The clinical features and course of the six anti‐p97/VCP‐positive PBC patients with Scheuer's stage 1 and 2 liver biopsies were monitored and it is suggested that this autoantibody might be an indicator of a favourable prognosis. Expand
Epitope‐specific anti‐nuclear antibodies are expressed in a mouse model of primary biliary cirrhosis and are cytokine‐dependent
TLDR
Transgenic mice with abrogated transforming growth factor‐β signalling in T cells that develop histological features of PBC are taken advantage to dissect the mechanisms of gp210 and sp100 autoantibody production in dnTGF‐βRII mice as well as to study the possible role of ANA in the pathophysiology of P BC. Expand
Primary biliary cirrhosis and autoantibodies.
TLDR
There is evidence that the existence of anti-gp210 antibodies are related to poorer prognosis and more aggressive disease progression, and enzyme linked immunosorbent assays that utilize recombinant gp210 should be particularly considered in anti-mitochondrial antibody negative PBC sera. Expand
Nuclear envelope protein autoantigens in primary biliary cirrhosis
  • H. Worman
  • Biology, Medicine
  • Hepatology research : the official journal of the Japan Society of Hepatology
  • 2007
TLDR
Recent data suggest that the presence of antinuclear envelope protein antibodies correlate with an unfavorable disease course and more rapid progression. Expand
Measurement of gp210 autoantibodies in sera of patients with primary biliary cirrhosis
TLDR
An immunoenzymatic assay for determination of gp210 autoantibodies using for its binding a synthetic pentadecapeptide derived from the gp210 amino acid sequence can be a reliable marker of PBC. Expand
Antibody titer to gp210-C terminal peptide as a clinical parameter for monitoring primary biliary cirrhosis.
TLDR
The serial quantitation of serum anti-gp210-C-terminal peptide antibodies is useful for monitoring the effect of UDCA and for the early identification of patients at high risk for end-stage hepatic failure. Expand
Primary biliary cirrhosis and the nuclear pore complex.
TLDR
The diagnostic and clinical relevance of anti-NPC antibodies in PBC are discussed and the possibility that this autoimmune response may arise as a result of molecular mimicry is considered. Expand
Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis.
TLDR
Autoantibodies to NPCs are more prevalent in PBC patients than in controls and are strongly associated with more active and severe disease. Expand
Autoantibodies in Primary Biliary Cirrhosis
TLDR
PBC-specific antinuclear antibodies (ANAs) are valuable as complementary serological markers for the definite diagnosis of AMA-negative PBC and should be advantageous for accurate and precise diagnoses and even for disease outcomes. Expand
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TLDR
These autoantibodies are highly specific for the diagnosis of PBC and may be useful in diagnosing individuals without antimitochondrial antibodies and in identifying a subgroup of patients with an increased incidence of associated arthritis. Expand
Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis.
TLDR
Analysis of the primary structure of the E2 components of all three 2-oxo acid dehydrogenase complexes reveals a high degree of homology with a similar highly segmented structure including lipoyl domains, E3-binding domains, C-terminal catalytic domains, and interdomain linker sequences. Expand
Identification and characterization of autoantibodies against the nuclear envelope lamin B receptor from patients with primary biliary cirrhosis
TLDR
Autoantibodies from two patients with primary biliary cirrhosis that recognize the nuclear envelope of mammalian cells on indirect immunofluorescence microscopy are identified, suggesting that antibodies against integral membrane proteins of thenuclear envelope are characteristic of a subset of patients with PBC. Expand
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A sensitive and reproducible assay for antibodies to mitochondria in patients with primary biliary cirrhosis is reported and it is believed that this recombinant protein is the first example of the use of designer molecules for immunodiagnosis. Expand
Autoantibodies to 200 kD polypeptide(s) of the nuclear envelope: a new serologic marker of primary biliary cirrhosis.
TLDR
It is shown that 10 sera contained antibodies to 200 kD polypeptide(s) of nuclear envelope, which can be considered as a new marker specific of a subset of primary biliary cirrhosis, being present even when anti-mitochondrial antibodies are absent. Expand
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TLDR
The results indicate that the use of recombinant, cloned autoantigens provides a simple, accurate, and rapid method of quantifying and monitoring the levels of specific mitochondrial autoantibodies in the serum of patients with primary biliary cirrhosis. Expand
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Serum samples from 94 patients with primary biliary cirrhosis (PBC) and 17 patients with chronic cholestatic hepatitis (CCH) were tested in the fluorometric immunoassay (FIAX) against theExpand
PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS
TLDR
Identification of the PBC-specific, immunoreactive, trypsin-sensitive antigens on the inner mitochondrial membrane (M2) should facilitate the development of a specific serological test for PBC and the study of autoimmunising epitopes. Expand
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TLDR
A sensitive enzyme linked immunosorbent assay for determination of low levels of anti-mitochondrial antibodies (AMA) has been developed and sera from patients with primary biliary cirrhosis and patients with different connective tissue diseases found to harbour high levels of AMA. Expand
Antimitochondrial autoantibodies in primary biliary cirrhosis recognize cross‐reactive epitope(s) on protein X and dihydrolipoamide acetyltransferase of pyruvate dehydrogenase complex
TLDR
The identification of protein X as another major target of the autoimmune response in primary biliary cirrhosis suggests that the pyruvate dehydrogenase complex may have a central role in the induction of this enigmatic disease. Expand
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