Autoantibodies against C1q in systemic lupus erythematosus are antigen-driven.

Abstract

Autoantibodies against complement C1q (anti-C1q Abs) were shown to strongly correlate with the occurrence of severe nephritis in patients with systemic lupus erythematosus (SLE), suggesting a potential pathogenic role by interfering with the complement cascade. To analyze the humoral immune response against C1q at the molecular level, we screened a bone… (More)
DOI: 10.4049/jimmunol.0902642

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