Autoamplification‐Enhanced Oxidative Kinetic Resolution of sec‐Alcohols and Alkyl Mandelates, and its Kinetic Model

@article{Talsi2018AutoamplificationEnhancedOK,
  title={Autoamplification‐Enhanced Oxidative Kinetic Resolution of sec‐Alcohols and Alkyl Mandelates, and its Kinetic Model},
  author={Evgenii P. Talsi and Konstantin P. Bryliakov},
  journal={ChemCatChem},
  year={2018},
  volume={10}
}
In this contribution, the new dynamic nonlinear effect in asymmetric catalysis is discussed, manifesting itself in the oxidative kinetic resolution (OKR) of racemic secondary benzylic alcohols and alkyl mandelates with H2O2 in the presence of chiral Mn‐based catalyst, with the apparent selectivity factor (krel) of the resolution being nonconstant over the reaction course. Typically, the initial growth of krel is changed into decay at high conversions. In this contribution, we demonstrate the… 
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Chiral Autoamplification Meets Dynamic Chirality Control to Suggest Nonautocatalytic Chemical Model of Prebiotic Chirality Amplification
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The reported catalyzed substrate self-enantioenrichment mechanism is discussed in relation to the problem of prebiotic chirality amplification and a consistent kinetic model for this process is presented.
Dynamic Nonlinear Effects in Asymmetric Catalysis
For three decades, “conventional” nonlinear effects in asymmetric catalysis, commonly becoming apparent as a nonproportional relationship between the enantiomeric purity of the chiral catalyst and…
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Resolving Oxygenation Pathways in Manganese-Catalyzed C(sp3)–H Functionalization via Radical and Cationic Intermediates
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Chemical Mechanisms of Prebiotic Chirality Amplification
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This work focuses on the chemical nature of possible mechanisms of primordial chirality enhancement, without going into detail of the preceding and subsequent phases of origination of biological homochirality and life on Earth.
Plant-Mediated Enantioselective Transformation of Indan-1-One and Indan-1-ol
The main purpose of this work was to discover the way to obtain pure enantiomers of indan-1-ol. The subject of the study was the ability of the plant enzyme system to reduce the carbonyl group of…
Recent advancement in oxidation or acceptorless dehydrogenation of alcohols to valorised products using manganese based catalysts
Rational Design of Bioinspired Catalysts for Selective Oxidations
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Manganese‐Catalyzed CH Oxygenation Reactions
  • K. Bryliakov
  • Chemistry
    Manganese Catalysis in Organic Synthesis
  • 2021

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