Autoaggressive myocytotoxic T lymphocytes expressing an unusual gamma/delta T cell receptor

@article{Pluschke1992AutoaggressiveMT,
  title={Autoaggressive myocytotoxic T lymphocytes expressing an unusual gamma/delta T cell receptor},
  author={G. Pluschke and D. Rüegg and R. Hohlfeld and A. Engel},
  journal={The Journal of Experimental Medicine},
  year={1992},
  volume={176},
  pages={1785 - 1789}
}
Polymyositis mediated by gamma/delta T cells is a unique disease in which autoaggressive T lymphocytes surround, invade, and destroy muscle fibers. Histochemically, the vast majority of muscle-infiltrating T cells in a patient with polymyositis were reactive with a pan- gamma/delta T cell receptor (TCR)-specific monoclonal antibody (TCR- delta 1+), but unlike > 90% of peripheral blood gamma/delta T cells, these lymphocytes did not react with V delta 1- or V gamma 9-specific antibodies (A13- and… Expand
An Autoreactive γδ TCR Derived from a Polymyositis Lesion1
Target Specificity of an Autoreactive Pathogenic Human γδ-T Cell Receptor in Myositis*
T-cell heterogeneity in muscle lesions of inclusion body myositis
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Polymyositis Mediated by T Lymphocytes That Express the γ/δ Receptor
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