Auto-silencing by the retinoid X receptor.

  title={Auto-silencing by the retinoid X receptor.},
  author={Sander Kersten and D Dong and Won Yong Lee and Peter R. Reczek and Noa Noy},
  journal={Journal of molecular biology},
  volume={284 1},
Gene transcription is often regulated by small ligands, enabling cells to respond to external and metabolic stimuli. Of particular interest are the mechanisms by which hydrophobic hormones modulate the transcriptional activities of proteins of the nuclear receptor superfamily. It was previously shown that, in the absence of ligand, the retinoid X receptor (RXRalpha) forms tetramers with a high affinity and a pronounced positive co-operativity such that tetramers become the receptor's… CONTINUE READING

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