Auto-brewery syndrome: Ethanol pseudo-toxicity in diabetic and hepatic patients

@article{Hafez2017AutobrewerySE,
  title={Auto-brewery syndrome: Ethanol pseudo-toxicity in diabetic and hepatic patients},
  author={Essam M. Hafez and M A Hamad and Mona A. Fouad and Ahmed Abdel-Lateff},
  journal={Human \& Experimental Toxicology},
  year={2017},
  volume={36},
  pages={445 - 450}
}
Endogenous alcohol has been applied for spontaneous ethanol production via different metabolic pathways of the human body. Auto-brewery syndrome describes the patients with alcohol intoxication after ingesting carbohydrate-rich meals. The main objective of this study is to investigate the effect of diabetes mellitus (DM), liver cirrhosis (LC) and presence of both (DM and LC) on blood alcohol concentration (BAC) especially after carbohydrate ingestion. BAC has been measured by headspace gas… 

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References

SHOWING 1-10 OF 28 REFERENCES
Endogenous ethanol fermentation in a child with short bowel syndrome.
TLDR
The possibility of endogenous ethanol fermentation should be considered in patients with SBS and the diagnosis of auto-brewery syndrome added to the differential diagnosis list for D-lactic acidosis.
Endogenous Ethanol ‘Auto-Brewery Syndrome’ as a Drunk-Driving Defence Challenge
TLDR
The notion that a motorist's state of intoxication was caused by endogenously produced ethanol lacks merit, as the concentrations of endogenous ethanol in peripheral venous blood of healthy individuals, as well as those suffering from various metabolic disorders (diabetes, hepatitis, cirrhosis) ranged from 0–0.08 mg/dl.
Producción endógena de alcohol en pacientes con cirrosis hepática, alteración motora y sobrecrecimiento bacteriano
TLDR
A low endogenous production of ethanol was demonstrated in six of eight patients with cirrhosis, consisting in changes in the migrating motor complex, as well as in two patients who had undetectable alcohol levels.
[Endogenous ethanol production in patients with liver cirrhosis, motor alteration and bacterial overgrowth].
TLDR
A low endogenous production of ethanol was demonstrated in six of eight patients with cirrhosis, consisting in changes in the migrating motor complex, as well as in two patients who had undetectable alcohol levels.
Endogenous ethanol production in a patient with chronic intestinal pseudo-obstruction and small intestinal bacterial overgrowth.
TLDR
The case of the gastrointestinal production of ethanol from Candida albicans and Saccharomyces cerevisiae in a Caucasian man with chronic intestinal pseudo-obstruction is reported, and a provocative test, performed by giving amoxicillin plus clavulanic acid associated with the simple sugar-rich diet was followed by the reappearance of ethanol in the blood.
Endogenous ethanol fermentation in a child with short bowel syndrome
TLDR
A case of a 3‐y‐old girl with short bowel syndrome (SBS) who demonstrated signs of alcohol intoxication on repeated occasions is presented.
Urinary Ethanol and Diabetes Mellitus
TLDR
Ethanol concentrations were assayed in urine samples obtained from 10 newly presenting diabetic patients with glycosuria and symptoms suggesting genito‐urinary candidiasis, and when stored at room temperature 8 out of 10 samples showed increasing levels of ethanol from day 3 to day 20.
Auto-brewery syndrome in a child with short gut syndrome: case report and review of the literature.
TLDR
The purpose of this article is to decribe one patient with auto-brewery syndrome and discuss its diagnosis and treatment.
...
...