Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.

  title={Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis.},
  author={Yvonne D{\"o}ring and Helga D Manthey and Maik Drechsler and Dirk Lievens and Remco T. A. Megens and Oliver Soehnlein and Martin Busch and Marco Manca and Rory R Koenen and Jaroslav Pelisek and M J A P Daemen and Esther Lutgens and Martin Zenke and Christoph J. Binder and Christian Weber and Alma Zernecke},
  volume={125 13},
BACKGROUND Inflammation has been closely linked to auto-immunogenic processes in atherosclerosis. Plasmacytoid dendritic cells (pDCs) are specialized to produce type-I interferons in response to pathogenic single-stranded nucleic acids, but can also sense self-DNA released from dying cells or in neutrophil extracellular traps complexed to the antimicrobial peptide Cramp/LL37 in autoimmune disease. However, the exact role of pDCs in atherosclerosis remains elusive. METHODS AND RESULTS Here we… CONTINUE READING
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