Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat.

@article{Yang1996AutoAC,
  title={Auto- and cross-spectral analysis of cardiovascular fluctuations during pentobarbital anesthesia in the rat.},
  author={C. C. Yang and Terry B. J. Kuo and Samuel H. H. Chan},
  journal={The American journal of physiology},
  year={1996},
  volume={270 2 Pt 2},
  pages={H575-82}
}
We applied auto- and cross-spectral analysis of systemic arterial pressure (SAP) and heart rate (HR) signals to quantify the effects of pentobarbital sodium on short-term cardiovascular fluctuations in adult, male Sprague-Dawley rats. Intravenous administration of pentobarbital, delivered as a bolus injection (5, 10, or 20 mg/kg) or continuous infusion (10, 20, or 40 mg.kg-1.h-1), elicited only mild hypotension and tachycardia. This was accompanied by a dose-related depression of the very low… CONTINUE READING

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