Auto‐transplantation of the uterus in the domestic pig (Sus scrofa): Surgical technique and early reperfusion events

  title={Auto‐transplantation of the uterus in the domestic pig (Sus scrofa): Surgical technique and early reperfusion events},
  author={Caiza Alm{\'e}n Wranning and Randa Racho El‐Akouri and Cecilia Lundmark and Pernilla Dahm-K{\"a}hler and Johan M{\"o}lne and Anders Enskog and Mats Br{\"a}nnstr{\"o}m},
  journal={Journal of Obstetrics and Gynaecology Research},
Aim:  To develop a method for auto‐transplantation of the uterus in the pig and to evaluate the early reperfusion events after short‐term cold ischemia. 

Transplantation of the uterus in sheep: Methodology and early reperfusion events

This study developed and evaluated autotransplantation of the sheep uterus to an orthotopic position in the pelvis and found it beneficial to use this model for research on uterine transplantation.

Test of long‐term uterine survival after allogeneic transplantation in rabbits

  • S. SasoS. Hurst J Richard Smith
  • Medicine, Biology
    The journal of obstetrics and gynaecology research
  • 2014
To see if: (i) a large vessel aortocaval vascular patch technique may bring about long‐term graft survival after allogeneic uterine transplantation (UTn) in a rabbit model; and (ii) fertility can be

Uterine transplantation: one human case followed by a decade of experimental research in animal models

The results of these specific studies on surgical technique, ischaemia‐reperfusion injury, immunosuppression and fertility are discussed.

Uterus Transplantation: An Update and Preparations for Introduction in India

The clinical field of composite tissue transplantation now also includes uterus transplantation (UTx), a new type of quality-oflife enhancing and in this case also life-giving transplantation. The

First report on fertility after allogeneic uterus transplantation

For the first time pregnancy after allogeneic uterus transplantation is described, as a proof of concept of uterine function in a transplanted uterus in a standardized animal model (rat) under immunosuppression.

Uterus transplantation: Toward clinical application in Japan

In recent years, uterus transplantation (UTx) has been applied as the treatment for patients with uterine factor infertility worldwide. Thus, the clinical application of UTx in Japan should be

Uterus transplantation in the baboon: methodology and long-term function after auto-transplantation.

This study demonstrates the feasibility of UTx by vascular anastomosis in a non-human primate species by developing surgical techniques for uterus retrieval and transplantation in the baboon.

Uterus Allo-Transplantation in a Swine Model: Long-Term Graft Survival and Reproductive Function

This study evaluated the safety and feasibility of the technology of allogeneic UTx, which was performed only by transplant uterine artery system from living-donor surgery in a swine model to show long-term survival and resumed estrous after UTx.

Laparoscopic uterine graft procurement and surgical autotransplantation in ovine model

The method used for laparoscopic live-donor ovariohysterectomy and graft harvest from a sheep model and an increase in the degree of fibrosis of the cervix samples in non-pregnant animals of the transplant group was noticed.

Sheep Model for Uterine Transplantation: The Best Option Before Starting a Human Program

The success of four uterine auto-transplants in sheep models is described and all four animals were alive after the surgical procedure and were euthanized after the experimental period.



Variability of the origin of the uterine artery: Laparoscopic surgical observation

Aim: To categorize the surgical anatomic variants of the origins of the uterine arteries and to clarify the difference in the description of the internal iliac artery in the contemporary

Heterotopic uterine transplantation by vascular anastomosis in the mouse.

An undisturbed function of the transplanted uterus horn was finally demonstrated by its ability to implant inserted blastocysts and to carry pregnancy with fetal weight being similar to that of fetuses in the native uterus and controls.

Implantation and early pregnancy in the autotransplanted uterus of the guinea-pig.

  • K. Bland
  • Medicine, Biology
    Journal of reproduction and fertility
  • 1972
Five guinea-pigs failed to return to oestrus after the final operation and, at autopsy, all three were found to be pregnant in the autotransplanted uterus, and the embryo in the third animal was degenerating although the placenta was still histologically normal.

Transplantation of the uterus

Genital organs. Auto and homotransplantation in forty dogs.

Graft function and viability was established by: X-ray examination, cytology of vaginal smears, the effect of gonadotropins on the grafted ovaries and finally relaparotomy undertaken after 3 weeks and 3 months.

Transplantation of the human uterus

  • W. FageehH. RaffaH. JabbadA. Marzouki
  • Medicine
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
  • 2002

Successful uterine transplantation in the mouse: pregnancy and post-natal development of offspring.

These observations document the capacity of a transplanted uterus to harbour pregnancies to term, and reveal that offspring from a transplants uterus develop to normal fertile adults.

Evolution: Its Complexity and Impact on Xenotransplantation

The goal of xenotransplantation is to resolve the shortage of donor organs and it is shown that survival and function time of discordant xenografts have been insignificantly prolonged to date.


Cold preservation of donor organs with PEG-supplemented solutions may help limit IRI in human renal transplantation and protect isolated perfused pig kidneys against cold ischemia and reperfusion injury.

Pregnancy in transplanted mouse uterus after long-term cold ischaemic preservation.

This study shows for the first time that the mouse uterus tolerates cold ischaemic preservation and that pregnancies can be carried in transplanted uteri that have been preserved for 24 h.