Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

  title={Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function},
  author={Hyejung Won and H Lee and Heon Yung Gee and Won Mah and Jae-Ick Kim and Jiseok Lee and Seungmin Ha and Changuk Chung and Eun Suk Jung and Yi Sul Cho and Sae-Geun Park and J Y Lee and Kyungmin Lee and Daesoo Kim and Yong Chul Bae and Bong-Kiun Kaang and Min Goo Lee and Eunjoon Kim},
Autism spectrum disorder (ASD) is a group of conditions characterized by impaired social interaction and communication, and restricted and repetitive behaviours. ASD is a highly heritable disorder involving various genetic determinants. Shank2 (also known as ProSAP1) is a multi-domain scaffolding protein and signalling adaptor enriched at excitatory neuronal synapses, and mutations in the human SHANK2 gene have recently been associated with ASD and intellectual disablility. Although ASD… CONTINUE READING
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Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

  • Bangash, A M.
  • Cell 145,
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