Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

  title={Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2},
  author={M. Schmeisser and E. Ey and Stephanie Wegener and J. Bockmann and A. Stempel and A. Kuebler and A. Janssen and Patrick T. Udvardi and E. Shiban and C. Spilker and D. Balschun and B. Skryabin and S. T. Dieck and K. Smalla and D. Montag and C. Leblond and P. Faure and N. Torquet and Anne-Marie Le Sourd and R. Toro and A. Grabrucker and S. A. Shoichet and D. Schmitz and M. Kreutz and T. Bourgeron and E. Gundelfinger and T. Boeckers},
  • M. Schmeisser, E. Ey, +24 authors T. Boeckers
  • Published 2012
  • Biology, Medicine
  • Nature
  • Autism spectrum disorders comprise a range of neurodevelopmental disorders characterized by deficits in social interaction and communication, and by repetitive behaviour. Mutations in synaptic proteins such as neuroligins, neurexins, GKAPs/SAPAPs and ProSAPs/Shanks were identified in patients with autism spectrum disorder, but the causative mechanisms remain largely unknown. ProSAPs/Shanks build large homo- and heteromeric protein complexes at excitatory synapses and organize the complex… CONTINUE READING
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