Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

  title={Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2},
  author={Michael Schmei\sser and Elodie Ey and Stephanie Wegener and Juergen Bockmann and A Vanessa Stempel and Angelika Kuebler and A Janssen and Patrick T. Udvardi and Youssef Shiban and Christina Spilker and Detlef Balschun and Boris V Skryabin and Susanne tom Dieck and K Kh Smalla and Dirk Montag and Claire S. Leblond and Philippe Faure and Nicolas Torquet and Anne-Marie Le Sourd and Roberto Toro and Andreas M Grabrucker and Sarah A. Shoichet and Dietmar Schmitz and Michael R Kreutz and Thomas Bourgeron and Eckart D. Gundelfinger and Tobias Maria Boeckers},
Autism spectrum disorders comprise a range of neurodevelopmental disorders characterized by deficits in social interaction and communication, and by repetitive behaviour. Mutations in synaptic proteins such as neuroligins, neurexins, GKAPs/SAPAPs and ProSAPs/Shanks were identified in patients with autism spectrum disorder, but the causative mechanisms remain largely unknown. ProSAPs/Shanks build large homo- and heteromeric protein complexes at excitatory synapses and organize the complex… CONTINUE READING
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