Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2

@article{Schmeier2012AutisticlikeBA,
  title={Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2},
  author={Michael Schmei\sser and Elodie Ey and Stephanie Wegener and Juergen Bockmann and A Vanessa Stempel and Angelika Kuebler and A Janssen and Patrick T. Udvardi and Youssef Shiban and Christina Spilker and Detlef Balschun and Boris V Skryabin and Susanne tom Dieck and K Kh Smalla and Dirk Montag and Claire S. Leblond and Philippe Faure and Nicolas Torquet and Anne-Marie Le Sourd and Roberto Toro and Andreas M Grabrucker and Sarah A. Shoichet and Dietmar Schmitz and Michael R Kreutz and Thomas Bourgeron and Eckart D. Gundelfinger and Tobias Maria Boeckers},
  journal={Nature},
  year={2012},
  volume={486},
  pages={256-260}
}
Autism spectrum disorders comprise a range of neurodevelopmental disorders characterized by deficits in social interaction and communication, and by repetitive behaviour. Mutations in synaptic proteins such as neuroligins, neurexins, GKAPs/SAPAPs and ProSAPs/Shanks were identified in patients with autism spectrum disorder, but the causative mechanisms remain largely unknown. ProSAPs/Shanks build large homo- and heteromeric protein complexes at excitatory synapses and organize the complex… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
Recent Discussions
This paper has been referenced on Twitter 17 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 191 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Genetic and functional analyses of SHANK2 mutations provide evidence for a multiple hit model of autism spectrum disorders

  • Leblond, S C.
  • PLoS Genet. 8,
  • 2012
1 Excerpt

Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation

  • Grabrucker, M A.
  • EMBO J. 30,
  • 2011

Enhanced polyubiquitination of Shank3 and NMDA receptor in a mouse model of autism

  • Bangash, A M.
  • Cell 145,
  • 2011

Similar Papers

Loading similar papers…