Autism spectrum disorders and autistic traits: A decade of new twin studies
@article{Ronald2011AutismSD, title={Autism spectrum disorders and autistic traits: A decade of new twin studies}, author={Angelica Ronald and Rosa A. Hoekstra}, journal={American Journal of Medical Genetics Part B: Neuropsychiatric Genetics}, year={2011}, volume={156} }
Researchers continue to pursue a better understanding of the symptoms, comorbidities, and causes of autism spectrum disorders. In this article we review more than 30 twin studies of autism spectrum disorders (ASDs) and autistic traits published in the last decade that have contributed to this endeavor. These twin studies have reported on the heritability of autism spectrum disorders and autistic traits in different populations and using different measurement and age groups. These studies have…
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References
SHOWING 1-10 OF 130 REFERENCES
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood.
- Medicine, PsychologyThe American journal of psychiatry
- 2010
Different neuropsychiatric disorders seem to have a common genetic etiology, suggesting caution in the use of diagnostic entities and proband status in efforts to uncover genes predisposing to autism spectrum disorders.
Genetic heterogeneity between the three components of the autism spectrum: a twin study.
- Psychology, MedicineJournal of the American Academy of Child and Adolescent Psychiatry
- 2006
The results suggest the triad of impairments that define autism spectrum disorders is heterogeneous genetically, and molecular genetic research examining the three aspects separately may identify different causal pathways for the three components.
Genetic correlation between autistic traits and IQ in a population-based sample of twins with autism spectrum disorders (ASDs)
- PsychologyJournal of Human Genetics
- 2009
There is a substantial overlap between the genetic factors that influence individual variation in autistic traits and IQ, irrespective of gender, and the individual life experiences that increase autistic traits have a moderate overlap with those that contribute to individual IQs.
Limited genetic covariance between autistic traits and intelligence: Findings from a longitudinal twin study
- PsychologyAmerican journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
- 2010
Investigation of the longitudinal association between autistic traits and intelligence in a general population twin sample and the etiology of this association suggest that individual differences in autistic traits are substantially genetically independent of intellectual functioning.
Relationship Between Symptom Domains in Autism Spectrum Disorders: A Population Based Twin Study
- PsychologyJournal of autism and developmental disorders
- 2009
Findings from a clinical sample of twins indicate a fractionation of social/communicative and RRBI symptoms in ASD.
On the twin risk in autism.
- Psychology, MedicineAmerican journal of human genetics
- 2002
The data clearly do not support twinning as a substantial risk factor in the etiology of autism, and it is demonstrated that the high proportion of twins found in affected-sib-pair studies can be adequately explained by the high ratio of concordance rates in monozygotic twins versus siblings and the distribution of family size in the population studied.
Evidence for overlapping genetic influences on autistic and ADHD behaviours in a community twin sample.
- Psychology, MedicineJournal of child psychology and psychiatry, and allied disciplines
- 2008
There are some common genetic influences operating across autistic traits and ADHD behaviours throughout normal variation and at the extreme, which is relevant for molecular genetic research, as well as for psychiatrists and psychologists, who may have assumed these two sets of behaviours are independent.
A twin study of autism symptoms in Sweden
- PsychologyMolecular Psychiatry
- 2011
It is suggested that the autism triad consists of three partly independent dimensions when assessed in the general population, and that these different autism symptoms, to a considerable extent, have partly separate genetic influences.
Autism as a strongly genetic disorder: evidence from a British twin study
- Medicine, PsychologyPsychological Medicine
- 1995
The findings indicate that autism is under a high degree of genetic control and suggest the involvement of multiple genetic loci.
The factor structure of autistic traits.
- PsychologyJournal of child psychology and psychiatry, and allied disciplines
- 2004
Future studies of the association between genetic/neurobiologic markers and autistic symptomatology may be enhanced by approaches which consider autistic symptoms as quantitative traits, and which are informed by ongoing research on the development and phenomenology of core deficiencies in reciprocal social behavior.