Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.

@article{Robinson2014AutismSD,
  title={Autism spectrum disorder severity reflects the average contribution of de novo and familial influences.},
  author={Elise B. Robinson and Kaitlin E. Samocha and Jack A. Kosmicki and Lauren M McGrath and Benjamin M. Neale and Roy H. Perlis and Mark J. Daly},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 42},
  pages={15161-5}
}
Autism spectrum disorders (ASDs) are a highly heterogeneous group of conditions--phenotypically and genetically--although the link between phenotypic variation and differences in genetic architecture is unclear. This study aimed to determine whether differences in cognitive impairment and symptom severity reflect variation in the degree to which ASD cases reflect de novo or familial influences. Using data from more than 2,000 simplex cases of ASD, we examined the relationship between… CONTINUE READING

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