Autism severity is associated with child and maternal MAOA genotypes

  title={Autism severity is associated with child and maternal MAOA genotypes},
  author={I. Bernard Cohen and X Liu and Mes Lewis and A E Chudley and Cynthia J Forster-Gibson and M Gonz{\'a}lez and E C Jenkins and W. Ted Brown and J. J. A. Holden},
  journal={Clinical Genetics},
Cohen IL, Liu X, Lewis MES, Chudley A, Forster‐Gibson C, Gonzalez M, Jenkins EC, Brown WT, Holden JJA. Autism severity is associated with child and maternal MAOA genotypes. 

Testing for association of the monoamine oxidase A promoter polymorphism with brain structure volumes in both autism and the fragile X syndrome

The MAOA promoter polymorphism is similarly associated with brain structure volumes in both idiopathic autism and FXS, and these data illuminate a number of important aspects of autism andFXS heritability.

Genetic Variants of Neurotransmitter-Related Genes and miRNAs in Egyptian Autistic Patients

Some neurotransmitter-related genes suggest their potential role in Autism pathogenesis that warrants further studies and much consideration, and threw light on MAOA uVNTR and miR-21.

Genetic variants of MAOB affect serotonin level and specific behavioral attributes to increase autism spectrum disorder (ASD) susceptibility in males

The Role of MAOA Gene in the Etiology of Autism Spectrum Disorder in Males

It seems that in Caucasian males, the risk of developing ASD increase with the presence of 4repeat allele in the promoter region of MAOA gene whereas no differences were found between autistic patients and controls in Egyptian, West Bengal and Korean population.

Genetic Aspects of Autism Spectrum Disorders: From Bench to Bedside

According to DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) and ICD-10 (International Classification of Diseases) autism includes symptoms of varying degrees in three categories:

Comparative immunogenetics of autism and schizophrenia

Systematic review of the literature indicates that reported associations of DRB1 variants with these three conditions are congruent with a pleiotropic model, and convergent findings from genetics and epidemiology imply that a subset of autism and schizophrenia cases may be underlain by genetically based neuroimmune alterations.

Etiologies underlying sex differences in Autism Spectrum Disorders

Etiology of Autism the Complexity of Risk Factors in Autism Spectrum Disorder

Autism Spectrum Disorder (ASD), also currently known as autism, refers to a group of complex behavioral disorders of varying severity, characterized by manifestations noted in early childhood,



Cortical enlargement in autism is associated with a functional VNTR in the monoamine oxidase A gene

  • L. DavisH. Hazlett T. Wassink
  • Biology, Psychology
    American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics
  • 2008
Genotyping the MAOA promoter polymorphism found a consistent association between the “low activity” allele and larger brain volumes for regions of the cortex in children with autism but not in controls.

Association of a Monoamine Oxidase-A Gene Promoter Polymorphism With ADHD and Anxiety in Boys With Autism Spectrum Disorder

The results support a growing body of research indicating that concomitant behavioral disturbances in children with ASD warrant consideration as clinical phenotypes, but replication with independent samples is necessary to confirm this preliminary finding.

MAOA is associated with methylphenidate improvement of oppositional symptoms in boys with attention deficit hyperactivity disorder.

An effect of the MAOA-uVNTR high-activity genotype on the improvement of oppositional symptoms with MPH treatment is suggested.

Modifier effects in autism at the MAO‐A and DBH loci

It is concluded that maternal genotypes at the MAO‐A locus, and possibly at the DBH one, may modify IQ in children with autism through the intrauterine environment.

Brief Report: Relationship Between Non-verbal IQ and Gender in Autism

Data suggest that MPX and SPX families differ with respect to the relationship between gender and IQ, and girls had lower IQ than boys, but no such differences were seen among MPX families.

MAOA and the neurogenetic architecture of human aggression

Maternal Recurrent Mood Disorders and High-Functioning Autism

It is hypothesized that genes associated with recurrent depression in women may exert a "protective" effect on cognition and adaptive functioning in children with PDD.

Parental care moderates the influence of MAOA-uVNTR genotype and childhood stressors on trait impulsivity and aggression in adult women

The results suggest that gene–environment interactions influence not only disadvantageous outcomes, but also sensitivity to features of the environment that could alleviate these outcomes.

Role of Genotype in the Cycle of Violence in Maltreated Children

A functional polymorphism in the gene encoding the neurotransmitter-metabolizing enzyme monoamine oxidase A was found to moderate the effect of maltreatment, and it was found that Maltreated children with a genotype conferring high levels of MAOA expression were less likely to develop antisocial problems.

Familial aggregation of quantitative autistic traits in multiplex versus simplex autism

Findings on patterns of familial aggregation of quantitative autistic traits (QAT) are consistent with the results of molecular genetic studies that have suggested differential modes of intergenerational transmission for SA and MA.