Autism-related behavioral abnormalities in synapsin knockout mice

@inproceedings{Greco2013AutismrelatedBA,
  title={Autism-related behavioral abnormalities in synapsin knockout mice},
  author={Barbara Greco and Francesca Manag{\`o} and Valter Tucci and H. M. Kao and Flavia Valtorta and Fabio Benfenati},
  booktitle={Behavioural Brain Research},
  year={2013}
}
Several synaptic genes predisposing to autism-spectrum disorder (ASD) have been identified. Nonsense and missense mutations in the SYN1 gene encoding for Synapsin I have been identified in families segregating for idiopathic epilepsy and ASD and genetic mapping analyses have identified variations in the SYN2 gene as significantly contributing to epilepsy predisposition. Synapsins (Syn I/II/III) are a multigene family of synaptic vesicle-associated phosphoproteins playing multiple roles in… CONTINUE READING