Autism and nutrition: the role of the gut–brain axis

  title={Autism and nutrition: the role of the gut–brain axis},
  author={Marijke M H van De Sande and Vincent J van Buul and Fred Brouns},
  journal={Nutrition Research Reviews},
  pages={199 - 214}
Autism spectrum disorder (ASD) is characterised by deficits in the ability to socialise, communicate and use imagination, and displays of stereotypical behaviour. It is widely accepted that ASD involves a disorder in brain development. However, the real causes of the neurodevelopmental disorders associated with ASD are not clear. In this respect, it has been found that a majority of children with ASD display gastrointestinal symptoms, and an increased intestinal permeability. Moreover, large… 

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Autism in Children Connected with Gastrointestinal Symptoms

The chapter presents eating dis- orders and nutritional deficiencies in children with ASD and shows how nutrition during pregnancy can affect ASD symptoms and how to reduce the severity of ASD symptoms through carefully selected nutritional interventions and supplementation.

Role of nutritional deficiency in the development of autism spectrum disorders

A narrative review was undertaken to highlight the role of nutritional deficiency in the development of ASD in children relevant literature was collected from Google scholar, Pubmed, Cross Ref and Scopus.

Microbiome and nutrition in autism spectrum disorder: current knowledge and research needs.

The current evidence base regarding the gut environment and nutritional status of children with ASD is reviewed and potential underlying mechanisms of the microbiota-gut-brain axis in ASD and the interplay between nutrition, microbiota, and ASD symptoms are reviewed.

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An intervention in the diet may not only improve the nutritional status of autistic patients but also relieve some gastrointestinal symptoms as well as improve sleep, inflexibility, self-injuring behavior, hyperactivity,irritability and other abnormal behaviors.

The role of intestinal flora in autism and nutritional approaches

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  • Medicine
    Demiroglu Science University Florence Nightingale Transplantation Journal
  • 2020
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Symbiosis in the microbiome of people with asd and its effects on the brain-intestine linkage

It will be necessary to offer a greater variety of fruits and vegetables to obtain adequate dosages of micronutrients through food intake, helping with homeostasis in the microbiota in order to achieve a symbiosis in the intestinal microbiome of the child with ASD.

Impact of Clostridium Bacteria in Children with Autism Spectrum Disorder and Their Anthropometric Measurements

If Clostridium bacteria play a potential role in the etiology of ASD, this may open the possibility for effective treatment of these patients, and the potential correlation between gut colonization ofclostridia and the probability of developing or exacerbating ASD among Egyptian children is emphasized.

Evaluating the effect of a prebiotic B-GOS in Autism Spectrum Disorders (ASDs)

It is demonstrated, for the first time, that a prebiotic B-GOS is able to modulate different aspects of autism and be considered as potential dietary therapeutic approach for ASD individuals.

The Possible Role of the Microbiota-Gut-Brain-Axis in Autism Spectrum Disorder

This paper suggests that ASD is associated with an unbalanced gut microbiota (dysbiosis), and the consumption of specific probiotics may represent a side-effect free tool to re-establish gut homeostasis and promote gut health.



Biochemical aspects in autism spectrum disorders: updating the opioid-excess theory and presenting new opportunities for biomedical intervention

The aim of this paper is to review the accompanying evidence in support of the opioid-excess theory of autism and present new directions of intervention as a result of it.

A Gluten-Free Diet as an Intervention for Autism and Associated Spectrum Disorders: Preliminary Findings

Results suggested that participants on a gluten-free diet showed an improvement on a number of behavioural measures, however there was no significant decrease in specific urinary compounds excreted when compared with controls and a gluten challenge group.

Alterations of the Intestinal Barrier in Patients With Autism Spectrum Disorders and in Their First-degree Relatives

It is indicated that measuring IPT could help to identify a subgroup of patients with autism who could benefit from a gluten-free diet and indicate the presence of an intestinal (tight-junction linked) hereditary factor in the families of subjects with autism.

Autism, an extreme challenge to integrative medicine. Part: 1: The knowledge base.

  • P. Kidd
  • Medicine, Psychology
    Alternative medicine review : a journal of clinical therapeutic
  • 2002
Part 2 of this review will attempt to consolidate progress in integrative management of autism, aimed at improving independence and lifespan for people with the disorder.

Food allergy and autism spectrum disorders: Is there a link?

  • H. Jyonouchi
  • Medicine, Psychology
    Current allergy and asthma reports
  • 2009
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Intestinal Pathophysiology in Autism

  • J. F. White
  • Medicine, Psychology
    Experimental biology and medicine
  • 2003
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Altered amino acid excretion in children with autism

It was concluded that the untreated autistic children had evidence of altered metabolic homeostasis.

Elimination diets in autism spectrum disorders: any wheat amidst the chaff?

Careful double-blind, placebo-controlled studies are needed to evaluate whether actual benefit undergirds the diets' popularity and to provide better guidance to clinicians and caregivers.