Autism and Metabolic Diseases

@article{Manzi2008AutismAM,
  title={Autism and Metabolic Diseases},
  author={Barbara Manzi and Anna Livia Loizzo and Grazia Giana and Paolo Curatolo},
  journal={Journal of Child Neurology},
  year={2008},
  volume={23},
  pages={307 - 314}
}
Autism is an etiologic heterogeneous entity caused by many different diseases occurring in the central nervous system at an early stage in life. Several metabolic defects have been associated with autistic symptoms with a rate higher than that found in the general population. Inborn errors of metabolism can probably account for less than 5% of individuals. Selective metabolic testing should be done in the presence of suggestive clinical findings, including lethargy, cyclic vomiting, early… 
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TLDR
To perform metabolic testing on 406 patients with nonsyndromic autism spectrum disorders (ASD) and review the hospital's clinical database of 8500 patients who had undergone metabolic testing to be identified for inborn errors of metabolism (IEM), the characteristics of those with IEM and nonsyNDromic ASD were described.
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