Autism: highly heritable but not inherited

@article{Beaudet2007AutismHH,
  title={Autism: highly heritable but not inherited},
  author={Arthur L Beaudet},
  journal={Nature Medicine},
  year={2007},
  volume={13},
  pages={534-536}
}
  • A. Beaudet
  • Published 1 May 2007
  • Biology, Medicine
  • Nature Medicine
The genetic basis of autism is beginning to come to light. De novo mutations in gene copy number may have a big role. 
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Copy-number variations associated with neuropsychiatric conditions
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Linkage and copy number variation analyses implicate chromosome 11p12–p13 and neurexins, respectively, among other candidate loci, highlighting glutamate-related genes as promising candidates for contributing to ASDs.
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It is proposed that both Autism and Rett syndrome result from disruption of postnatal or experience-dependent synaptic plasticity, and at the phenotypic and pathogenic levels.
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