Autism, Alzheimer disease, and fragile X: APP, FMRP, and mGluR5 are molecular links.

Abstract

The present review highlights an association between autism, Alzheimer disease (AD), and fragile X syndrome (FXS). We propose a conceptual framework involving the amyloid-β peptide (Aβ), Aβ precursor protein (APP), and fragile X mental retardation protein (FMRP) based on experimental evidence. The anabolic (growth-promoting) effect of the secreted α form of… (More)
DOI: 10.1212/WNL.0b013e3182166dc7

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