Authorization and Toxicity of Veterinary Drugs and Plant Protection Products: Residues of the Active Ingredients in Food and Feed and Toxicity Problems Related to Adjuvants

  title={Authorization and Toxicity of Veterinary Drugs and Plant Protection Products: Residues of the Active Ingredients in Food and Feed and Toxicity Problems Related to Adjuvants},
  author={Szandra Kl{\'a}tyik and P{\'e}ter Bohus and B{\'e}la Darvas and Andr{\'a}s Sz{\'e}k{\'a}cs},
  journal={Frontiers in Veterinary Science},
Chemical substances applied in animal husbandry or veterinary medicine and in crop protection represent substantial environmental loads, and their residues occur in food and feed products. Product approval is governed differently in these two sectors in the European Union (EU), and the occurrence of veterinary drug (VD) and pesticide residues indicated by contamination notification cases in the Rapid Alert System for Food and Feed of the EU also show characteristic differences. While the… 
Mechanism-related Teratogenic, Hormone Modulant and other Toxicological effects of Veterinary and agricultural surfactants
Toxicological effects identified in studies in aquatic toxicity tests, in cell viability and cytotoxicity tests, and in estrogenic activity assays, correlated with biochemical analysis of the surfactants and their decomposition are summarized to facilitate environmentally precautious revision of surfactant widely used in agriculture.
Magnitude and decline of pesticide co‐formulant residues in vegetables and fruits: results from field trials compared to estimated values
The findings from field trials, as well as the presented approach for the prediction of residues, provide key elements for future consideration of consumer exposure to PPP co‐formulants.
Re-registration Challenges of Glyphosate in the European Union
The precautionary principle appears to be the optimal approach in this case for regulation in the EU in relation to re-registration of the active herbicide ingredient glyphosate.
Multiclass and multi-residue screening of mycotoxins, pharmacologically active substances, and pesticides in infant milk formulas through ultra-high-performance liquid chromatography coupled with high-resolution mass spectrometry analysis.
Infant milk formulas are designed to substitute human milk when breastfeeding is unavailable. In addition to human milk and milk-derived products, these formulas can be a vehicle of contaminants. In
Research directions in plant protection chemistry
This Opinion paper briefly summarizes the views of the authors on the directions of research in the area of plant protection chemistry. We believe these directions need to focus on (1) the discovery
Quality Management in Spice Paprika Production: From Cultivation to End Product
There is ample historical and scientifically proven information regarding the health benefits of spice paprika, including favourable physiological effects, anti-oxidant and antiinflammatory
Commercial glyphosate-based herbicides effects on springtails (Collembola) differ from those of their respective active ingredients and vary with soil organic matter content
It is suggested that ERAs for pesticides should be performed with actually applied herbicides rather than only on AIs and should also consider influences of different soil properties.
Entomopathogenic Fungi for Pests and Predators Control in Beekeeping
The aim of this review is to describe the state of the art on the topic under investigation, which is entomopathogenic organisms that are environmentally friendly and are capable of stopping the expression of resistance once it has evolved.
Creation of Trichoderman: From an Idea to Realization
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    Journal of Biotechnology & Bioresearch
  • 2020
The creation of Trichoderma fungi via genetic transformation of superior isolates by the genetic constructs for the expression and secretion of insect-specific insecticidal peptides (Trichodermans) can improve their effectiveness in the control of insect pest targets.


Comparison of the legal regulations of pesticides and hazardous chemicals in the European Union with emphasis on genotoxic and endocrine disrupting effects
Pesticide producers cannot ignore their possible obligations under the REACH regulation controlling registration, evaluation and authorization of chemicals, as only the active ingredients (and not
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Regulation (EC) 1107/2009 lays down the main instruments for placing effective plant protection products (using pesticide substances) on the market that are safe for humans, animals and the
Environmental and Toxicological Impacts of Glyphosate with Its Formulating Adjuvant
The results indicate that toxicity of the formulated herbicide is caused by the formulating agent, but in some parameters toxicological synergy occurs between POEA and glyphosate.
Perspectives in Veterinary Pharmacology and Toxicology
During the last years, the following new antimicrobial active substances have been authorized for use in veterinary medicine: difloxacin (belonging to the class fluoroquinolones), valnemulin (a pleuromutilin, 1999), pirlimycin (a lincosamide, 2001), and tildipirosin (a macrolide, 2011).
Effects of neonicotinoid insecticide formulations and their components on Daphnia magna – the role of active ingredients and co-formulants
ABSTRACT Formulating agents used in pesticide products have been regarded as inactive/inert components; however, several studies confirmed additive, synergistic or antagonistic effects between the
Veterinary Pharmaceuticals in the Environment
This paper presents an overview of the fate and effects of antimicrobials used in aquaculture, and risks of agricultural pharmaceuticals in surface water systems and soils, in Aquatic Plants Exposed to Veterinary Antibiotics.
Co-Formulants in Glyphosate-Based Herbicides Disrupt Aromatase Activity in Human Cells below Toxic Levels
It was demonstrated for the first time that endocrine disruption by GBH could not only be due to the declared active ingredient but also to co-formulants, challenging the relevance of the acceptable daily intake (ADI) value for GBHs exposures, currently calculated from toxicity tests of the declaredactive ingredient alone.
Fate, behavior and effects of surfactants and their degradation products in the environment.
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    Environment international
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