Aurothiolates inhibit HIV-1 infectivity by gold(I) ligand exchange with a component of the virion surface.

@article{Okada1993AurothiolatesIH,
  title={Aurothiolates inhibit HIV-1 infectivity by gold(I) ligand exchange with a component of the virion surface.},
  author={Tomoko Okada and Bruce K. Patterson and Shui Qing Ye and Mark E Gurney},
  journal={Virology},
  year={1993},
  volume={192 2},
  pages={631-42}
}
Aurothioglucose and aurothiomalate have anti-HIV-1 activity in vitro. Antiviral activity requires the formation of a reactive intermediate with a molar equivalent amount of a thiol ligand. This activates gold(I) ligand exchange between the reactive species bis(thiolato)gold(I) and acidic thiol groups exposed on the surface of proteins. Bis(thioglucose)gold(I) (bisAuTG) which is formed by the reaction of molar equivalent amounts of aurothioglucose and 1-thio-beta-D-glucose completely protected… CONTINUE READING
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