Aurora kinases as targets for cancer therapy.

  title={Aurora kinases as targets for cancer therapy.},
  author={Giannis Mountzios and Evangelos Terpos and Meletios Athanasios Dimopoulos},
  journal={Cancer treatment reviews},
  volume={34 2},
Aurora kinases represent a family of serine/threonine kinases highly conserved during evolution, whose main function is to promote mitotic spindle assembly by regulating centrosome duplication and separation. Inhibition of Aurora kinase activity may lead to defects in centrosome function, misaligned sister chromatids, mitotic spindle malformation, problematic cytokinesis and eventually mitotic arrest. Aurora kinases are overexpressed in a variety of tumor cell lines, suggesting their potential… CONTINUE READING
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