Aurora kinases and their inhibitors: more than one target and one drug.

@article{Carpinelli2008AuroraKA,
  title={Aurora kinases and their inhibitors: more than one target and one drug.},
  author={Patrizia Carpinelli and J{\"u}rgen Moll},
  journal={Advances in experimental medicine and biology},
  year={2008},
  volume={610},
  pages={54-73}
}
Dependent on the degree of inhibition of different Aurora kinase family members, various events in mitosis are affected, resulting in differential cellular responses. These different cellular responses have to be considered in the clinical development of the small molecule inhibitors with respect to the chosen indications, schedules and appropriate endpoints. Here the properties of the most advanced small molecule Aurora kinase inhibitors are compared and a case report on the development of PHA… CONTINUE READING

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