Aurora kinases: new targets for cancer therapy.

@article{Carvajal2006AuroraKN,
  title={Aurora kinases: new targets for cancer therapy.},
  author={Richard D. Carvajal and Archie N. Tse and Gary K. Schwartz},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2006},
  volume={12 23},
  pages={
          6869-75
        }
}
The Aurora kinase family is a collection of highly related serine/threonine kinases that functions as a key regulator of mitosis. In mammalian cells, Aurora has evolved into three related kinases known as Aurora-A, Aurora-B, and Aurora-C. These kinases are overexpressed in a number of human cancers, and transfection studies have established Aurora-A as a bone fide oncogene. Because Aurora overexpression is associated with malignancy, these kinases have been targeted for cancer therapy. This… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 140 CITATIONS, ESTIMATED 50% COVERAGE

FILTER CITATIONS BY YEAR

2005
2019

CITATION STATISTICS

  • 11 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 49 REFERENCES

MLN 8054 selectively inhibits Aurora A overAurora B in cultured human tumor cells [ abstract C 40 ]

  • HM Hoar, DR Wysong, JA Ecsedy
  • Proc AACRNCIEORTC International Conference…
  • 2005