Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish

@article{Gwee2018AuroraKB,
  title={Aurora kinase B regulates axonal outgrowth and regeneration in the spinal motor neurons of developing zebrafish},
  author={Serene S. L. Gwee and Rowan A W Radford and Sharron Chow and Monisha D. Syal and Marco Morsch and Isabel Formella and Albert Lee and Emily K. Don and Andrew P. Badrock and Nicholas J Cole and Adrian K. West and Steve N. S. Cheung and Roger S. Chung},
  journal={Cellular and Molecular Life Sciences},
  year={2018},
  volume={75},
  pages={4269 - 4285}
}
Aurora kinase B (AurkB) is a serine/threonine protein kinase with a well-characterised role in orchestrating cell division and cytokinesis, and is prominently expressed in healthy proliferating and cancerous cells. [] Key Result AurkB was prominently expressed within post-mitotic neurons of the zebrafish brain and spinal cord. The expression of AurkB varied during the development of the zebrafish spinal motor neurons.

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It is demonstrated that WNT signalling drives a distinct form of non-directional cell motility that requires a key centrosome module, but not microtubules or centrosomes, which is surprisingly shown to control migration after recruitment by Wnt-PCP proteins to the cell cortex, leading to actin remodelling and protrusive activity relevant to aggressive cancer motility.

Salivary glands require Aurora Kinase B for regeneration after transient innate immune-mediated injury

The present study examined the initial mitogenic events marking the regenerative response of the murine submandibular gland (SMG), following innate immune-mediated injury and cellular depletion in response to poly (I:C) injury.