Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.

@article{Solc2012AuroraKA,
  title={Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.},
  author={Petr Solc and Vladim{\'i}r Baran and Alexandra Mayer and Tereza Bohmova and Gabriela Panenkova-Havlova and Ad{\'e}la Saskov{\'a} and Richard M Schultz and Jan Motl{\'i}k},
  journal={Biology of reproduction},
  year={2012},
  volume={87 4},
  pages={
          85
        }
}
Aurora kinase A (AURKA) is an important mitotic kinase involved in the G2/M transition, centrosome maturation and separation, and spindle formation in somatic cells. We used transgenic models that specifically overexpress in mouse oocytes either wild-type (WT-AURKA) or a catalytically inactive (kinase-dead) (KD-AURKA) AURKA to gain new insights regarding the role of AURKA during oocyte maturation. AURKA activation occurs shortly after hCG administration that initiates maturation in vivo… CONTINUE READING

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