Aurora-C kinase supports mitotic progression in the absence of Aurora-B.

  title={Aurora-C kinase supports mitotic progression in the absence of Aurora-B.},
  author={Scott D Slattery and Michael A. Mancini and Bill R. Brinkley and Rebecca M Hall},
  journal={Cell cycle},
  volume={8 18},
Aurora family kinases regulate numerous mitotic processes, and their dysfunction or overexpression can cause aneuploidy, a contributing factor for tumorigenesis. In vertebrates, the Aurora-B kinase regulates kinetochore maturation, destabilization of improper kinetochore-microtubule attachments, the spindle assembly checkpoint, central spindle organization and cytokinesis. A gene duplication event created the related Aurora-C kinase in mammals. While Aurora-C function is unclear, it has similar… CONTINUE READING


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