Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration.

@article{Li2009AuroraAOI,
  title={Aurora-A overexpression in mouse liver causes p53-dependent premitotic arrest during liver regeneration.},
  author={Chao-Chin Li and Hui-Yi Chu and Chu-Wen Yang and Chen-Kung Chou and Ting-Fen Tsai},
  journal={Molecular cancer research : MCR},
  year={2009},
  volume={7 5},
  pages={
          678-88
        }
}
Aurora-A, a serine-threonine kinase, is frequently overexpressed in human cancers, including hepatocellular carcinoma. To study the phenotypic effects of Aurora-A overexpression on liver regeneration and tumorigenesis, we generated transgenic mice overexpressing human Aurora-A in the liver. The overexpression of Aurora-A after hepatectomy caused an earlier entry into S phase, a sustaining of DNA synthesis, and premitotic arrest in the regenerating liver. These regenerating transgenic livers… CONTINUE READING

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