Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer.

@article{Tseng2006AuroraAOA,
  title={Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer.},
  author={Ya-Shih Tseng and C. Tzeng and C. F. Huang and Ping-Hong Chen and Allen Wen-hsiang Chiu and Pei-Yin Hsu and Guan-Cheng Huang and Yu-chun Wang and Hsiao-Sheng Liu},
  journal={Cancer letters},
  year={2006},
  volume={241 1},
  pages={93-101}
}
Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a… CONTINUE READING