Aurora A kinase (AURKA) in normal and pathological cell division

  title={Aurora A kinase (AURKA) in normal and pathological cell division},
  author={Anna S. Nikonova and Igor A Astsaturov and Ilya G. Serebriiskii and Roland L. Dunbrack and Erica A Golemis},
  journal={Cellular and Molecular Life Sciences},
Temporally and spatially controlled activation of the Aurora A kinase (AURKA) regulates centrosome maturation, entry into mitosis, formation and function of the bipolar spindle, and cytokinesis. Genetic amplification and mRNA and protein overexpression of Aurora A are common in many types of solid tumor, and associated with aneuploidy, supernumerary centrosomes, defective mitotic spindles, and resistance to apoptosis. These properties have led Aurora A to be considered a high-value target for… CONTINUE READING


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