Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces

@inproceedings{Asteriti2011AuroraAIC,
  title={Aurora-A inactivation causes mitotic spindle pole fragmentation by unbalancing microtubule-generated forces},
  author={Italia Anna Asteriti and Maria Giubettini and Patrizia Lavia and Giulia Guarguaglini},
  booktitle={Molecular Cancer},
  year={2011}
}
Aurora-A is an oncogenic kinase playing well-documented roles in mitotic spindle organisation. We previously found that Aurora-A inactivation yields the formation of spindles with fragmented poles that can drive chromosome mis-segregation. Here we have addressed the mechanism through which Aurora-A activity regulates the structure and cohesion of spindle poles. We inactivated Aurora-A in human U2OS osteosarcoma cells either by RNA-interference-mediated silencing or treating cultures with the… CONTINUE READING