Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition

@inproceedings{Sourisseau2010AuroraAET,
  title={Aurora-A expressing tumour cells are deficient for homology-directed DNA double strand-break repair and sensitive to PARP inhibition},
  author={Tony Sourisseau and Despina Maniotis and Afshan Mccarthy and Chan Tang and Christopher J Lord and Alan Ashworth and Spiros Linardopoulos},
  booktitle={EMBO molecular medicine},
  year={2010}
}
The protein kinase Aurora-A is a major regulator of the cell cycle that orchestrates mitotic entry and is required for the assembly of a functional mitotic spindle. Overexpression of Aurora-A has been strongly linked with oncogenesis and this has led to considerable efforts at therapeutic targeting of the kinase activity of this protein. However, the exact mechanism by which Aurora-A promotes oncogenesis remains unclear. Here, we show that Aurora-A modulates the repair of DNA double-strand… CONTINUE READING

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