Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics

@inproceedings{Hgarat2011AuroraAA,
  title={Aurora A and Aurora B jointly coordinate chromosome segregation and anaphase microtubule dynamics},
  author={Nadia H{\'e}garat and Ewan Smith and Gowri Nayak and Shunichi Takeda and Patrick A Eyers and Helfrid Hochegger},
  booktitle={The Journal of cell biology},
  year={2011}
}
We established a conditional deletion of Aurora A kinase (AurA) in Cdk1 analogue-sensitive DT40 cells to analyze AurA knockout phenotypes after Cdk1 activation. In the absence of AurA, cells form bipolar spindles but fail to properly align their chromosomes and exit mitosis with segregation errors. The resulting daughter cells exhibit a variety of phenotypes and are highly aneuploid. Aurora B kinase (AurB)-inhibited cells show a similar chromosome alignment problem and cytokinesis defects… CONTINUE READING